Welcome to the SwissBioisostere database

This website provides access to our knowledgebase of molecular replacements, useful for compound optimization in drug design.

Two different queries are possible:

• you are interested in a range of possible replacements for a single substructure ( e.g. different replacements for an amide group )
• you want to know details about a particular substructural replacement of interest ( e.g. Carboxylic acid vs. Tetrazole )

Depending on your question, please enter either one or two substructures of interest in the following molecular sketchers. By submitting via "Query Database" the database will be queried.


Please indicate attachment points in your substructures by R-groups R1-R3.

Examples can be found here.

Fragment 1		Fragment 2

Applet sketchers have been replaced by JavaScript versions. The old startpage can be found here.